An AKAP79-based peptide with analgesic activity
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Tat-AKAP79 (326-336) (trifluoroacetate salt)

Item No. 37444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Tat-A-kinase Anchor Protein 79 (326-336)
Molecular Formula
C117H211N49O34S • XCF3COOH
Formula Weight
2880.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRKSKSEESKRME-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC1=CC=C(O)C=C1)N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C117H211N49O34S.C2HF3O2/c1-201-56-43-80(106(195)163-81(110(199)200)38-42-89(177)178)162-100(189)76(30-18-55-145-117(137)138)152-94(183)68(21-4-9-46-120)157-108(197)83(60-168)166-105(194)79(37-41-88(175)176)160-104(193)78(36-40-87(173)174)161-109(198)84(61-169)165-102(191)70(23-6-11-48-122)158-107(196)82(59-167)164-101(190)69(22-5-10-47-121)150-95(184)71(25-13-50-140-112(127)128)153-97(186)73(27-15-52-142-114(131)132)154-98(187)74(28-16-53-143-115(133)134)156-103(192)77(35-39-85(124)171)159-99(188)75(29-17-54-144-116(135)136)155-96(185)72(26-14-51-141-113(129)130)151-93(182)67(20-3-8-45-119)149-92(181)66(19-2-7-44-118)148-91(180)65(24-12-49-139-111(125)126)147-86(172)58-146-90(179)64(123)57-62-31-33-63(170)34-32-62;3-2(4,5)1(6)7/h31-34,64-84,167-170H,2-30,35-61,118-123H2,1H3,(H2,124,171)(H,146,179)(H,147,172)(H,148,180)(H,149,181)(H,150,184)(H,151,182)(H,152,183)(H,153,186)(H,154,187)(H,155,185)(H,156,192)(H,157,197)(H,158,196)(H,159,188)(H,160,193)(H,161,198)(H,162,189)(H,163,195)(H,164,190)(H,165,191)(H,166,194)(H,173,174)(H,175,176)(H,177,178)(H,199,200)(H4,125,126,139)(H4,127,128,140)(H4,129,130,141)(H4,131,132,142)(H4,133,134,143)(H4,135,136,144)(H4,137,138,145);(H,6,7)/t64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-;/m0./s1
InChi Key
SBYQMBVYNQGWOO-YEHJQBOZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $492

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    Product Description

    Tat-AKAP79 (326-336) is a peptide composed of the HIV-1 Tat protein transduction domain linked to an 11-amino acid peptide corresponding to residues 326-336 of A-kinase anchor protein 79 (AKAP79).1 It inhibits protein kinase A (PKA) or PKC activation-induced sensitization of transient receptor potential vanilloid 1 (TRPV1) in isolated rat dorsal root ganglion (DRG) neurons when used at a concentration of 200 µM. In vivo, Tat-AKAP79 (326-336) inhibits nocifensive behavior induced by formalin or phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in mice. It also increases the latency to paw withdrawal from a radiant heat stimulus and increases the mechanical threshold force to paw withdrawal in a mouse model of carrageenan-induced inflammatory pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Btesh, J., Fischer, M.J.M., Stott, K., et al. Mapping the binding site of TRPV1 on AKAP79: Implications for inflammatory hyperalgesia. J. Neurosci. 33(21), 9184-9193 (2013).