A peptide inhibitor of the MD-2-CIRP protein-protein interaction
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Tat-CIRP (trifluoroacetate salt)

Item No. 37446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Tat-Cold-inducible RNA Binding Protein
Molecular Formula
C123H206N56O33 • XCF3COOH
Formula Weight
2997.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRGRGFSRGGGDRGYGG-OH
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
OC(C(F)(F)F)=O.O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CC=C(O)C=C3)N[H]
InChi Code
InChI=1S/C123H206N56O33.C2HF3O2/c124-40-6-4-19-76(172-104(202)75(25-12-46-150-119(136)137)165-92(188)59-158-98(196)70(126)51-66-30-34-68(181)35-31-66)105(203)173-77(20-5-7-41-125)106(204)174-79(27-14-48-152-121(140)141)108(206)176-81(29-16-50-154-123(144)145)110(208)178-82(38-39-87(127)183)111(209)177-80(28-15-49-153-122(142)143)109(207)175-78(26-13-47-151-120(138)139)107(205)169-72(22-9-43-147-116(130)131)101(199)162-60-93(189)164-71(21-8-42-146-115(128)129)99(197)161-62-95(191)167-84(52-65-17-2-1-3-18-65)112(210)179-86(64-180)114(212)171-74(24-11-45-149-118(134)135)100(198)159-56-89(185)155-55-88(184)156-58-91(187)168-85(54-96(192)193)113(211)170-73(23-10-44-148-117(132)133)102(200)163-61-94(190)166-83(53-67-32-36-69(182)37-33-67)103(201)160-57-90(186)157-63-97(194)195;3-2(4,5)1(6)7/h1-3,17-18,30-37,70-86,180-182H,4-16,19-29,38-64,124-126H2,(H2,127,183)(H,155,185)(H,156,184)(H,157,186)(H,158,196)(H,159,198)(H,160,201)(H,161,197)(H,162,199)(H,163,200)(H,164,189)(H,165,188)(H,166,190)(H,167,191)(H,168,187)(H,169,205)(H,170,211)(H,171,212)(H,172,202)(H,173,203)(H,174,204)(H,175,207)(H,176,206)(H,177,209)(H,178,208)(H,179,210)(H,192,193)(H,194,195)(H4,128,129,146)(H4,130,131,147)(H4,132,133,148)(H4,134,135,149)(H4,136,137,150)(H4,138,139,151)(H4,140,141,152)(H4,142,143,153)(H4,144,145,154);(H,6,7)/t70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-;/m0./s1
InChi Key
DQQPZSFEUNTIEF-OVJMHBTRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

    $235

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    10 mg

    $440

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    Product Description

    Tat-CIRP is a peptide inhibitor of the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP).1 It binds to MD-2 and disrupts the interaction between MD-2 and CIRP in co-immunoprecipitation assays. In vivo, Tat-CIRP (10 and 20 mg/kg) reduces infarct volume in a mouse model of stroke induced by middle cerebral artery occlusion (MCAO). It also reduces infarct volume and decreases the time to pick up and withdraw food with the stroke-affected arm in a rhesus monkey model of thrombosis-induced stroke.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fang, Z., Wu, D., Deng, J., et al. An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Sci. Transl Med. 13(597), eabb6716 (2021).