A peptide inhibitor of DRP1
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P110 (trifluoroacetate salt)

Item No. 37450

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,12S,15S,18S,21S,24S,27S,30S,33S,36S,42S)-42-amino-3-(((S)-1-(((S)-1-((S)-2-(((S)-1-((2-(((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-21-(3-amino-3-oxopropyl)-30,33-bis(4-aminobutyl)-12,15,18,24,27,36-hexakis(3-guanidinopropyl)-43-(4-hydroxyphenyl)-5,8,11,14,17,20,23,26,29,32,35,38,41-tridecaoxo-4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaazatritetracontanoic acid, trifluoroacetate salt
Molecular Formula
C100H179N45O25 • XCF3COOH
Formula Weight
2411.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRGGDLLPRGS-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.O=C([C@@H](N[H])CC1=CC=C(C=C1)O)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N[C@H](C(NCC(N[C@H](C(N)=O)CO)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN[H])=O)CCCCN[H])=O)CCCNC(N)=N)=O
InChi Code
InChI=1S/C100H179N45O25.C2HF3O2/c1-52(2)43-67(90(167)144-69(44-53(3)4)93(170)145-42-16-26-71(145)92(169)142-58(20-10-36-121-95(108)109)81(158)130-50-76(152)133-70(51-146)78(105)155)143-91(168)68(46-77(153)154)132-74(150)48-127-73(149)47-129-80(157)57(19-9-35-120-94(106)107)134-85(162)62(22-12-38-123-97(112)113)138-87(164)64(24-14-40-125-99(116)117)140-89(166)66(31-32-72(104)148)141-88(165)65(25-15-41-126-100(118)119)139-86(163)63(23-13-39-124-98(114)115)137-84(161)61(18-6-8-34-102)136-83(160)60(17-5-7-33-101)135-82(159)59(21-11-37-122-96(110)111)131-75(151)49-128-79(156)56(103)45-54-27-29-55(147)30-28-54;3-2(4,5)1(6)7/h27-30,52-53,56-71,146-147H,5-26,31-51,101-103H2,1-4H3,(H2,104,148)(H2,105,155)(H,127,149)(H,128,156)(H,129,157)(H,130,158)(H,131,151)(H,132,150)(H,133,152)(H,134,162)(H,135,159)(H,136,160)(H,137,161)(H,138,164)(H,139,163)(H,140,166)(H,141,165)(H,142,169)(H,143,168)(H,144,167)(H,153,154)(H4,106,107,120)(H4,108,109,121)(H4,110,111,122)(H4,112,113,123)(H4,114,115,124)(H4,116,117,125)(H4,118,119,126);(H,6,7)/t56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-;/m0./s1
InChi Key
CIVMOPZZMWNWNB-AUKHCSASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $184

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    25 mg

    $316

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    Product Description

    P110 is a peptide inhibitor of the mitochondrial GTPase dynamin-related protein 1 (DRP1).1 It selectively inhibits DRP1 GTPase activity over the additional mitochondrial GTPases OPA1, MFN1, and dynamin 1 at 1 µM. P110 (1 µM) inhibits the MPP+-induced protein-protein interaction between DRP1 and mitochondrial fission 1 (FIS1), as well as MPP+-, carbonyl cyanide M-chloro phenyl hydrazone-, rotenone-, or hydrogen peroxide-induced DRP1 translocation to the mitochondria in SH-SY5Y cells. It also inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qi, X., Qvit, N., Su, Y.-C., et al. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J. Cell Sci. 126(3), 789-802 (2013).