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(±)-Methadone (hydrochloride)

Item No. 37451

Restricted Product (Schedule II)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • DL-Methadone
  • NSC 19600
Technical Information
Formal Name
6-(dimethylamino)-4,4-diphenyl-3-heptanone, monohydrochloride
CAS Number
1095-90-5
Molecular Formula
C21H27NO • HCl
Formula Weight
345.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
CCC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CC(N(C)C)C)=O.Cl
InChi Code
InChI=1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H
InChi Key
FJQXCDYVZAHXNS-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (±)-Methadone (hydrochloride) (Item No. 37451) is an analytical reference standard categorized as an opioid.1 (±)-Methadone has analgesic activity.2 Formulations containing (±)-methadone have been used in the treatment of opioid addiction. (±)-Methadone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raynor, K., Kong, H., Chen, Y., et al. Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol. Pharm. 45(2), 330-334 (1994).

    2. He, L., Kim, J., Ou, C., et al. Methadone antinociception is dependent on peripheral opioid receptors. J. Pain. 10(4), 369-379 (2009).

    Product Citations

    Vandeputte, M.M., Walton, S.E., Shuda, S.A., et al. Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs. Anal. Bioanal. Chem. (2023).