A quorum-sensing peptide
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PapRIV (trifluoroacetate salt)

Item No. 37453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-4-((S)-2-((S)-1-(L-seryl-L-aspartyl-L-leucyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-(((S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl)amino)-5-oxopentanoic acid
Molecular Formula
C38H53N9O13 • XCF3COOH
Formula Weight
843.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
SDLPFEH-OH
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C([C@@H](N)CO)N[C@H](C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(O)=O)CC3=CNC=N3)=O)CCC(O)=O)=O)=O)=O)=O)CC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C38H53N9O13.C2HF3O2/c1-20(2)13-27(45-35(56)26(16-31(51)52)43-32(53)23(39)18-48)37(58)47-12-6-9-29(47)36(57)44-25(14-21-7-4-3-5-8-21)34(55)42-24(10-11-30(49)50)33(54)46-28(38(59)60)15-22-17-40-19-41-22;3-2(4,5)1(6)7/h3-5,7-8,17,19-20,23-29,48H,6,9-16,18,39H2,1-2H3,(H,40,41)(H,42,55)(H,43,53)(H,44,57)(H,45,56)(H,46,54)(H,49,50)(H,51,52)(H,59,60);(H,6,7)/t23-,24-,25-,26-,27-,28-,29-;/m0./s1
InChi Key
JGBRZAJJPGVQEE-WXZWFHAESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    PapRIV is a quorum-sensing heptapeptide originally isolated from B. cereus.1 It is translated as a 48-amino acid polypeptide, which is secreted and extracellularly processed by NprB proteases to form the active heptapeptide.2 PapRIV (1-25 µM) induces IL-6 and TNF-α production by, and NF-κB translocation in, BV-2 microglia cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Janssens, Y., Debunne, N., De Spiegeleer, A., et al. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci. Rep. 11(1), 10723 (2021).

    2. Pomerantsev, A.P., Pomerantseva, O.M., Camp, A.S., et al. PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation. FEMS Immunol. Med. Microbiol. 55(3), 361-377 (2009).