An antimicrobial peptide
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SMAP 29 (ovine) (trifluoroacetate salt)

Item No. 37462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginylglycyl-L-leucyl-L-arginyl-L-arginyl-L-leucylglycyl-L-arginyl-L-lysyl-L-isoleucyl-L-alanyl-L-histidylglycyl-L-valyl-L-lysyl-L-lysyl-L-tyrosylglycyl-L-prolyl-L-threonyl-L-valyl-L-leucyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-arginyl-L-isoleucyl-L-alanyl-glycine, trifluoroacetate salt
Synonyms
  • Sheep Myeloid Antimicrobial Peptide 29
Molecular Formula
C146H260N52O32 • XCF3COOH
Formula Weight
3256.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
RGLRRLGRKIAHGVKKYGPTVLRIIRIAG-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.O=C(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC2=CC=C(O)C=C2)C(NCC(N3CCC[C@H]3C(N[C@]([C@H](O)C)([H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@H](C(NCC(O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)[C@H](CCCNC(N)=N)N[H]
InChi Code
InChI=1S/C146H260N52O32.C2HF3O2/c1-22-80(15)112(136(226)176-84(19)117(207)174-73-109(205)206)194-130(220)98(47-37-61-169-146(161)162)186-138(228)114(82(17)24-3)196-139(229)115(83(18)25-4)195-129(219)97(46-36-60-168-145(159)160)184-132(222)101(65-77(9)10)190-135(225)111(79(13)14)192-140(230)116(86(21)199)197-133(223)104-48-38-62-198(104)108(204)72-173-121(211)102(66-87-49-51-89(200)52-50-87)189-126(216)92(40-26-29-53-147)180-124(214)93(41-27-30-54-148)185-134(224)110(78(11)12)191-107(203)71-172-122(212)103(67-88-68-163-74-175-88)187-118(208)85(20)177-137(227)113(81(16)23-2)193-128(218)94(42-28-31-55-149)181-123(213)91(43-33-57-165-142(153)154)178-105(201)70-171-120(210)99(63-75(5)6)188-127(217)96(45-35-59-167-144(157)158)182-125(215)95(44-34-58-166-143(155)156)183-131(221)100(64-76(7)8)179-106(202)69-170-119(209)90(150)39-32-56-164-141(151)152;3-2(4,5)1(6)7/h49-52,68,74-86,90-104,110-116,199-200H,22-48,53-67,69-73,147-150H2,1-21H3,(H,163,175)(H,170,209)(H,171,210)(H,172,212)(H,173,211)(H,174,207)(H,176,226)(H,177,227)(H,178,201)(H,179,202)(H,180,214)(H,181,213)(H,182,215)(H,183,221)(H,184,222)(H,185,224)(H,186,228)(H,187,208)(H,188,217)(H,189,216)(H,190,225)(H,191,203)(H,192,230)(H,193,218)(H,194,220)(H,195,219)(H,196,229)(H,197,223)(H,205,206)(H4,151,152,164)(H4,153,154,165)(H4,155,156,166)(H4,157,158,167)(H4,159,160,168)(H4,161,162,169);(H,6,7)/t80-,81-,82-,83-,84-,85-,86+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,110-,111-,112-,113-,114-,115-,116-;/m0./s1
InChi Key
YIZVWGVJQMQEFS-QXLCWWTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    SMAP 29 is an antimicrobial peptide and a C-terminal cleavage product of an ovine cathelicidin prepropeptide.1,2,3 SMAP 29 is bactericidal to P. aeruginosa strain PAO1 under low- and high-salt conditions in an energy-dependent luminescence assay (EC50s = 0.05 and 0.06 µM, respectively).2 It induces hemolysis in ovine red blood cells in a concentration-dependent manner.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahoney, M.M., Lee, A.Y., Brezinski-Caliguri, D.J., et al. Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide. FEBS Lett. 377(3), 519-522 (1995).

    2. Travis, S.M., Anderson, N.N., Forsyth, W.R., et al. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect. Immun. 68(5), 2748-2755 (2000).

    3. Dawson, R.M., and Liu, C.-Q. Cathelicidin peptide SMAP-29: Comprehensive review of its properties and potential as a novel class of antibiotics. Drug Dev. Res. 70(7), 481-498 (2009).

    4. Jung, B., Yun, H., Min, H.J., et al. Discovery of structural and functional transition sites for membrane-penetrating activity of sheep myeloid antimicrobial peptide-18. Sci. Rep. 13(1), 1238 (2023).