An inhibitor of the Cav2.2-CRMP2 protein-protein interaction
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Myr-Tat-CBD3 (trifluoroacetate salt)

Item No. 37465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-myristoyl-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alanyl-L-arginyl-L-seryl-L-arginyl-L-leucyl-L-alanyl-L-α-glutamyl-L-leucyl-L-arginylglycyl-L-valyl-L-prolyl-L-arginylglycyl-L-leucine, trifluoroacetate salt
Synonyms
  • N-myristate-Tat-CBD3
  • Myr-Tat-Calcium Channel-binding Domain 3
Molecular Formula
C148H269N59O33 • XCF3COOH
Formula Weight
3403.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
myristoyl-YGRKKRRQRRRARSRLAELRGVPRGL-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.CCCCCCCCCCCCCC(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C(C)C)C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C148H269N59O33.C2HF3O2/c1-12-13-14-15-16-17-18-19-20-21-22-51-110(211)188-105(76-87-52-54-88(209)55-53-87)120(221)184-77-111(212)187-91(42-29-64-174-141(156)157)122(223)193-92(38-23-25-60-149)123(224)194-93(39-24-26-61-150)124(225)196-97(46-33-68-178-145(164)165)126(227)198-99(48-35-70-180-147(168)169)128(229)201-101(56-58-109(151)210)131(232)199-98(47-34-69-179-146(166)167)127(228)197-96(45-32-67-177-144(162)163)125(226)195-94(43-30-65-175-142(158)159)121(222)185-85(10)116(217)190-95(44-31-66-176-143(160)161)130(231)205-107(80-208)135(236)200-100(49-36-71-181-148(170)171)129(230)203-103(73-81(2)3)133(234)186-86(11)117(218)191-102(57-59-114(215)216)132(233)204-104(74-82(4)5)134(235)192-89(40-27-62-172-139(152)153)118(219)183-79-113(214)206-115(84(8)9)137(238)207-72-37-50-108(207)136(237)202-90(41-28-63-173-140(154)155)119(220)182-78-112(213)189-106(138(239)240)75-83(6)7;3-2(4,5)1(6)7/h52-55,81-86,89-108,115,208-209H,12-51,56-80,149-150H2,1-11H3,(H2,151,210)(H,182,220)(H,183,219)(H,184,221)(H,185,222)(H,186,234)(H,187,212)(H,188,211)(H,189,213)(H,190,217)(H,191,218)(H,192,235)(H,193,223)(H,194,224)(H,195,226)(H,196,225)(H,197,228)(H,198,227)(H,199,232)(H,200,236)(H,201,229)(H,202,237)(H,203,230)(H,204,233)(H,205,231)(H,206,214)(H,215,216)(H,239,240)(H4,152,153,172)(H4,154,155,173)(H4,156,157,174)(H4,158,159,175)(H4,160,161,176)(H4,162,163,177)(H4,164,165,178)(H4,166,167,179)(H4,168,169,180)(H4,170,171,181);(H,6,7)/t85-,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-;/m0./s1
InChi Key
XNWNMTKREBTRTN-NHAGQNHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $492

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    Product Description

    Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2).1 It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons (IC50 = ~2.8 µM). Myr-Tat-CBD3 (20 µM) inhibits calcium, but not sodium, currents in primary DRG neurons. Intrathecal administration of myr-Tat-CBD3 (20 µg/5 µl) prevents carrageenan-induced decreases in paw withdrawal latencies in rats. Myr-Tat-CBD3 decreases cue-induced reinstatement of cocaine-seeking behavior in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. François-Moutal, L., Wang, Y., Moutal, A., et al. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain 156(7), 1247-1264 (2015).

    2. Buchta, W.C., Moutal, A., Hines, B., et al. Dynamic CRMP2 regulation of CaV2.2 in the prefrontal cortex contributes to the reinstatement of cocaine seeking. Mol. Neurobiol. 57(1), 346-357 (2020).