An ACE2-based peptide
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SBP1 (trifluoroacetate salt)

Item No. 37469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Spike Binding Peptide 1
Molecular Formula
C127H185N31O41 • XCF3COOH
Formula Weight
2802.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
IEEQAKTFLDKFNHEAEDLFYQS-NH2
Solubility(Learn about Variance in Solubility)
10% ACN/H2O: soluble
SMILES
[H]N[C@]([C@H](CC)C)([H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N)=O)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)=O)=O)C)=O)=O)CC3=CN=CN3)=O)=O)CC4=CC=CC=C4)=O)=O)CC(O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C127H185N31O41.C2HF3O2/c1-10-65(6)103(133)126(198)146-82(41-47-100(171)172)112(184)143-81(40-46-99(169)170)111(183)142-77(36-42-94(130)162)108(180)137-66(7)106(178)139-76(31-21-23-49-129)115(187)158-104(68(9)160)127(199)156-88(54-71-28-18-13-19-29-71)121(193)147-84(51-64(4)5)117(189)155-91(58-101(173)174)124(196)141-75(30-20-22-48-128)110(182)149-85(52-69-24-14-11-15-25-69)120(192)153-90(57-96(132)164)123(195)152-89(56-73-60-135-62-136-73)122(194)145-79(38-44-97(165)166)109(181)138-67(8)107(179)140-80(39-45-98(167)168)113(185)154-92(59-102(175)176)125(197)148-83(50-63(2)3)116(188)150-86(53-70-26-16-12-17-27-70)119(191)151-87(55-72-32-34-74(161)35-33-72)118(190)144-78(37-43-95(131)163)114(186)157-93(61-159)105(134)177;3-2(4,5)1(6)7/h11-19,24-29,32-35,60,62-68,75-93,103-104,159-161H,10,20-23,30-31,36-59,61,128-129,133H2,1-9H3,(H2,130,162)(H2,131,163)(H2,132,164)(H2,134,177)(H,135,136)(H,137,180)(H,138,181)(H,139,178)(H,140,179)(H,141,196)(H,142,183)(H,143,184)(H,144,190)(H,145,194)(H,146,198)(H,147,193)(H,148,197)(H,149,182)(H,150,188)(H,151,191)(H,152,195)(H,153,192)(H,154,185)(H,155,189)(H,156,199)(H,157,186)(H,158,187)(H,165,166)(H,167,168)(H,169,170)(H,171,172)(H,173,174)(H,175,176);(H,6,7)/t65-,66-,67-,68+,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,103-,104-;/m0./s1
InChi Key
HLZXLHCUBVBNAP-JCDVQLKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Spike binding peptide 1 (SBP1) is a peptide that corresponds to amino acids 21-43 of angiotensin-converting enzyme 2 (ACE2).1 Lipid nanoparticles (LNPs) encapsulating the antiviral compound oseltamivir phosphate have been conjugated to SBP1 and studied in vitro to estimate their potential for providing controlled, long-term release of oseltamivir phosphate in vivo.1 SBP1 (2%) immobilized to crosslinked networks of hydroxy acrylate and ethylxanthate ethyl acrylate, increases network capture efficiency of severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ucar, B., Acar, T., Arayici, P.P., et al. A nanotechnological approach in the current therapy of COVID-19: Model drug oseltamivir-phosphate loaded PLGA nanoparticles targeted with spike protein binder peptide of SARS-CoV-2. Nanotechnology 32(48), 485601 (2021).

    2. Rahman, M.S., Rajawasam, C.W.H., De Alwis Watuthanthrige, N., et al. SARS-CoV-2 spike protein capture by peptide functionalized networks. J. Polym. Sci. 61(5), 391-397 (2023).