A cyclic peptide
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation
Innate Immunity

Tiger17 (trifluoroacetate salt)

Item No. 37473

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6S,9R,14R,17S,19aS,25S,27aS,33S,35aS)-N-((S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-9-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-6,25,33-tris(4-aminobutyl)-17-(3-guanidinopropyl)-5,8,16,19,24,27,32,35-octaoxodotriacontahydro-13H-tripyrrolo[2,1-j:2',1'-p:2'',1''-v][1,2]dithia[5,8,11,14,17,20,23,26]octaazacyclononacosine-14-carboxamide, trifluoroacetate salt
Synonyms
  • H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
Molecular Formula
C62H97N21O11S2 • XCF3COOH
Formula Weight
1376.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
WCKPKPKPRCH-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N2[C@](CCC2)([H])C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@H](CSSC4)C(N[C@H](C(N)=O)CC5=CN=CN5)=O)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)=O)CCCCN)=O)=O)CCCCN)[C@H]4NC([C@@H](N)CC6=CNC7=CC=CC=C67)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C62H97N21O11S2.C2HF3O2/c63-22-6-3-15-42-59(92)82-27-11-20-49(82)57(90)77-44(17-5-8-24-65)61(94)83-28-12-21-50(83)58(91)76-43(16-4-7-23-64)60(93)81-26-10-19-48(81)56(89)74-41(18-9-25-71-62(68)69)53(86)80-47(55(88)78-45(51(67)84)30-37-32-70-35-73-37)34-96-95-33-46(54(87)75-42)79-52(85)39(66)29-36-31-72-40-14-2-1-13-38(36)40;3-2(4,5)1(6)7/h1-2,13-14,31-32,35,39,41-50,72H,3-12,15-30,33-34,63-66H2,(H2,67,84)(H,70,73)(H,74,89)(H,75,87)(H,76,91)(H,77,90)(H,78,88)(H,79,85)(H,80,86)(H4,68,69,71);(H,6,7)/t39-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-;/m0./s1
InChi Key
XDGCNTXTAHYYKA-CTLJWZNGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Tiger17 is a cyclic peptide and derivative of tigerinin-RC1 and tigerinin-RC2, which are antimicrobial peptides found in crab-eating frog (F. cancrivora) skin secretions.1 It increases the proliferation of HaCaT keratinocytes and human skin fibroblasts when used at concentrations ranging from 5 to 20 µg/ml and increases HaCaT cell migration at 20 µg/ml. Tiger17 increases the recruitment of, and the secretion of TGF-β1 and IL-6 from, RAW 264.7 macrophages. Topical application of tiger17 (20 µg/ml) increases the rate of wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. J., T., H., L., C., G., et al. A small peptide with potential ability to promote wound healing. PLoS One 9(3), e92082 (2014).