An inhibitor of the protein-protein interaction between c-Myc and Max
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

10074-A4

Item No. 37486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-2,4-thiazolidinedione
CAS Number
312631-87-1
Molecular Formula
C18H14Cl2N2O3S
Formula Weight
409.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
233, 240 nm
SMILES
O=C1SCC(N1CC(CN2C3=CC=C(C=C3C4=C2C=CC(Cl)=C4)Cl)O)=O
InChi Code
InChI=1S/C18H14Cl2N2O3S/c19-10-1-3-15-13(5-10)14-6-11(20)2-4-16(14)21(15)7-12(23)8-22-17(24)9-26-18(22)25/h1-6,12,23H,7-9H2
InChi Key
SCNHANGMZXFWOH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $179

    Add

    10 mg

    $315

    Add

    25 mg

    $689

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    10074-A4 is an inhibitor of the protein-protein interaction between c-Myc and the c-Myc associated protein Max.1 It inhibits c-Myc and Max heterodimerization when used at a concentration of 5 µM and reduces the proliferation of Rat1 and TGR-1 rat fibroblasts but not TGR-1 Myc knockout fibroblasts at 32 µM. 10074-A4 (32 µM) reduces the expression of the gene encoding ornithine decarboxylase (ODC), a c-Myc and Max target gene, and induces cell cycle arrest at the G0/G1 phase in Myc-overexpressing Rat1 cells. Preincubation of 10074-A4 (32 µM) with Myc-overexpressing Rat1 cells in vitro reduces tumor growth of the same cells in a mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yin, X., Giap, C., Lazo, J.S., et al. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22(40), 6151-6159 (2003).