A peptide substrate for PKCγ, PKCδ, PKCε, PKCη, and PKCξ
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
Cell Signaling

Application

Enzyme Activity

[Ser159]-PKCε (149-164) (trifluoroacetate salt)

Item No. 37508

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-arginyl-L-methionyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-seryl-L-valyl-L-arginyl-L-arginyl-L-arginyl-L-valine, trifluoroacetate salt
Synonyms
  • [Ser159]-PKCε Pseudosubstrate Peptide (149-164)
  • [Ser159]-Protein Kinase Cɛ Inhibitor Peptide (149-164)
Molecular Formula
C83H155N39O21S • XCF3COOH
Formula Weight
2067.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
ERMRPRKRQGSVRRRV-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C83H155N39O21S.C2HF3O2/c1-42(2)60(74(140)118-50(21-12-35-105-81(95)96)69(135)113-47(18-9-32-102-78(89)90)66(132)114-51(22-13-36-106-82(97)98)71(137)121-61(43(3)4)76(142)143)120-72(138)55(41-123)109-58(125)40-108-63(129)52(26-27-57(86)124)115-67(133)48(19-10-33-103-79(91)92)112-64(130)45(16-6-7-30-84)111-68(134)49(20-11-34-104-80(93)94)117-73(139)56-24-15-38-122(56)75(141)54(23-14-37-107-83(99)100)119-70(136)53(29-39-144-5)116-65(131)46(17-8-31-101-77(87)88)110-62(128)44(85)25-28-59(126)127;3-2(4,5)1(6)7/h42-56,60-61,123H,6-41,84-85H2,1-5H3,(H2,86,124)(H,108,129)(H,109,125)(H,110,128)(H,111,134)(H,112,130)(H,113,135)(H,114,132)(H,115,133)(H,116,131)(H,117,139)(H,118,140)(H,119,136)(H,120,138)(H,121,137)(H,126,127)(H,142,143)(H4,87,88,101)(H4,89,90,102)(H4,91,92,103)(H4,93,94,104)(H4,95,96,105)(H4,97,98,106)(H4,99,100,107);(H,6,7)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-;/m0./s1
InChi Key
GSRYZJIMSSMPAY-OTHXIIPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $139

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    10 mg

    $261

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    25 mg

    $611

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    Product Description

    [Ser159]-PKCε (149-164) is a peptide substrate for PKCγ, PKCδ, PKCε, PKCη, and PKCξ, serine/threonine kinases involved in various cell processes such as proliferation, differentiation, and survival.1,2,3 It has been used as a target substrate for the quantification of PKCγ, PKCδ, PKCε, PKCη, or PKCξ activity in cell-free or cell-based assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakanishi, H., Brewer, K.A., and Exton, J.H. Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemisty 268(1), 13-16 (1993).

    2. Luo, Y., Smith, R.A., Guan, R., et al. Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition. Biochemistry 43(5), 1254-1263 (2004).

    3. Lee, A.W. The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages. PLoS One 6(10), e25580 (2011).