A peptide activator of Bak
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
Cell Death
Apoptosis

PUMA BH3 (human) (trifluoroacetate salt)

Item No. 37509

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-arginyl-L-α-glutamyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-leucyl-L-arginyl-L-arginyl-L-methionyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-leucyl-L-asparaginyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-α-glutamyl-L-arginine, trifluoroacetate salt
Molecular Formula
C128H202N42O43S • XCF3COOH
Formula Weight
3049.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
EEQWAREIGAQLRRMADDLNAQYER-OH
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)C)=O)=O)=O)CC(O)=O)=O)CC(O)=O)=O)C)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C128H202N42O43S.C2HF3O2/c1-12-60(6)100(170-115(203)79(35-42-97(183)184)159-107(195)71(21-15-44-142-125(134)135)152-102(190)62(8)150-116(204)85(52-66-56-146-70-20-14-13-19-68(66)70)167-114(202)76(32-38-91(132)174)158-110(198)77(33-40-95(179)180)155-105(193)69(129)29-39-94(177)178)123(211)147-57-93(176)148-61(7)101(189)153-74(30-36-89(130)172)112(200)164-82(49-58(2)3)118(206)157-73(23-17-46-144-127(138)139)108(196)156-72(22-16-45-143-126(136)137)109(197)161-80(43-48-214-11)106(194)149-64(10)104(192)163-87(54-98(185)186)121(209)169-88(55-99(187)188)122(210)165-83(50-59(4)5)119(207)168-86(53-92(133)175)117(205)151-63(9)103(191)154-75(31-37-90(131)173)113(201)166-84(51-65-25-27-67(171)28-26-65)120(208)160-78(34-41-96(181)182)111(199)162-81(124(212)213)24-18-47-145-128(140)141;3-2(4,5)1(6)7/h13-14,19-20,25-28,56,58-64,69,71-88,100,146,171H,12,15-18,21-24,29-55,57,129H2,1-11H3,(H2,130,172)(H2,131,173)(H2,132,174)(H2,133,175)(H,147,211)(H,148,176)(H,149,194)(H,150,204)(H,151,205)(H,152,190)(H,153,189)(H,154,191)(H,155,193)(H,156,196)(H,157,206)(H,158,198)(H,159,195)(H,160,208)(H,161,197)(H,162,199)(H,163,192)(H,164,200)(H,165,210)(H,166,201)(H,167,202)(H,168,207)(H,169,209)(H,170,203)(H,177,178)(H,179,180)(H,181,182)(H,183,184)(H,185,186)(H,187,188)(H,212,213)(H4,134,135,142)(H4,136,137,143)(H4,138,139,144)(H4,140,141,145);(H,6,7)/t60-,61-,62-,63-,64-,69-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,100-;/m0./s1
InChi Key
SDYLFIZJHKVDLG-OZRNRZLFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

    $249

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    10 mg

    $440

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    25 mg

    $964

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    Product Description

    PUMA BH3 is a peptide comprising the BH3 domain of p53-upregulated modulator of apoptosis (PUMA) and an activator of the pro-apoptotic protein Bak.1 PUMA BH3 binds to Bak (Kds = 290 and 26 nM in HEPES and CHAPS buffer, respectively) and induces Bak homo-oligomerization and Bak-mediated membrane permeabilization.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dai, H., Pang, Y.-P., Ramirez-Alvarado, M., et al. Evaluation of the BH3-only protein Puma as a direct Bak activator. The Journal of Biological Chemisty 289(1), 89-99 (2014).