An antimicrobial peptide
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SAAP 148 (trifluoroacetate salt)

Item No. 37517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-N1-((S)-1-(((S)-6-amino-1-(((S)-7-amino-1-((S)-1-(((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)pyrrolidin-2-yl)-1,2-dioxoheptan-3-yl)amino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-2-((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,47S,50S)-5,38-bis((1H-indol-3-yl)methyl)-14,23,35,47-tetrakis(4-aminobutyl)-26-benzyl-2,11,32,44-tetrakis(3-guanidinopropyl)-8-(4-hydroxybenzyl)-17,20,50-triisobutyl-29,41-diisopropyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-heptadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-heptadecaazatripentacontanamido)pentanediamide, trifluoroacetate salt
Synonyms
  • Synthetic Antimicrobial and Antibiofilm Peptide 148
Molecular Formula
C157H261N49O27 • XCF3COOH
Formula Weight
3267.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@@H]1CCCN1C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC(C)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CC6=CNC7=C6C=CC=C7)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C157H261N49O27.C2HF3O2/c1-87(2)77-116(183-94(15)207)140(221)188-105(47-23-29-65-158)131(212)186-113(57-39-75-180-157(174)175)139(220)204-127(92(11)12)151(232)202-123(84-98-86-182-103-46-22-20-44-101(98)103)147(228)192-107(49-25-31-67-160)132(213)187-112(56-38-74-179-156(172)173)138(219)203-126(91(9)10)150(231)201-121(81-95-41-17-16-18-42-95)144(225)191-109(51-27-33-69-162)135(216)196-119(80-90(7)8)143(224)198-118(79-89(5)6)142(223)189-106(48-24-30-66-159)130(211)185-111(55-37-73-178-155(170)171)136(217)199-120(82-96-59-61-99(208)62-60-96)145(226)200-122(83-97-85-181-102-45-21-19-43-100(97)102)146(227)193-110(54-36-72-177-154(168)169)133(214)194-114(63-64-125(164)209)137(218)197-117(78-88(3)4)141(222)190-108(50-26-32-68-161)134(215)195-115(52-28-34-70-163)152(233)206-76-40-58-124(206)148(229)205-128(93(13)14)149(230)184-104(129(165)210)53-35-71-176-153(166)167;3-2(4,5)1(6)7/h16-22,41-46,59-62,85-93,104-124,126-128,181-182,208H,23-40,47-58,63-84,158-163H2,1-15H3,(H2,164,209)(H2,165,210)(H,183,207)(H,184,230)(H,185,211)(H,186,212)(H,187,213)(H,188,221)(H,189,223)(H,190,222)(H,191,225)(H,192,228)(H,193,227)(H,194,214)(H,195,215)(H,196,216)(H,197,218)(H,198,224)(H,199,217)(H,200,226)(H,201,231)(H,202,232)(H,203,219)(H,204,220)(H,205,229)(H4,166,167,176)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)(H4,174,175,180);(H,6,7)/t104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,126-,127-,128-;/m0./s1
InChi Key
OQCYASNUGXFPSN-SEJZRRKPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    SAAP 148 is an antimicrobial peptide.1 It is active against several multidrug-resistant bacteria in vitro. In vivo, SAAP 148 (0.125-2% w/w) decreases the number of skin colony-forming units (CFUs) in mouse models of A. baumannii or methicillin-resistant S. aureus (MRSA) infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Breij, A., Riool, M., Cordfunke, R.A., et al. The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci. Transl. Med. 10(423), eaan4044 (2018).