A fluorogenic substrate for MMP-3
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MMP-3 Fluorogenic Substrate (trifluoroacetate salt)

Item No. 37523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-valyl-L-α-glutamyl-L-norvalyl-L-tryptophyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysinamide, trifluoroacetate salt
Synonyms
  • Matrix Metalloproteinase-3 Fluorogenic Substrate
  • Mca-RPKPVE-Nval-WR-K(Dnp)-NH2
  • Stromelysin-1 Fluorogenic Substrate
Molecular Formula
C78H110N22O20 • XCF3COOH
Formula Weight
1675.9
Purity
≥95%
Emission
420 nm
Excitation
328 nm
Formulation (Request formulation change)
A solid
Peptide Sequence
McaRPKPVENvalWRK(Dnp)-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
λmax
220 nm
SMILES
NC([C@H](CCCCNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](CCCCN)NC([C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC(CC(C4=CC=C(OC)C=C4O5)=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C78H110N22O20.C2HF3O2/c1-5-16-53(68(106)95-58(37-45-42-88-50-18-7-6-17-48(45)50)71(109)92-54(21-12-33-86-77(81)82)69(107)90-52(67(80)105)19-9-11-32-85-51-28-25-46(99(115)116)40-61(51)100(117)118)91-70(108)55(29-30-64(102)103)93-74(112)66(43(2)3)96-73(111)60-24-15-36-98(60)76(114)57(20-8-10-31-79)94-72(110)59-23-14-35-97(59)75(113)56(22-13-34-87-78(83)84)89-63(101)38-44-39-65(104)120-62-41-47(119-4)26-27-49(44)62;3-2(4,5)1(6)7/h6-7,17-18,25-28,39-43,52-60,66,85,88H,5,8-16,19-24,29-38,79H2,1-4H3,(H2,80,105)(H,89,101)(H,90,107)(H,91,108)(H,92,109)(H,93,112)(H,94,110)(H,95,106)(H,96,111)(H,102,103)(H4,81,82,86)(H4,83,84,87);(H,6,7)/t52-,53-,54-,55-,56-,57-,58-,59-,60-,66-;/m0./s1
InChi Key
RQAYJVJJNNJVIL-QFOZWALASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    MMP-3 fluorogenic substrate is a fluorogenic substrate for matrix metalloproteinase-3 (MMP-3).1 Upon cleavage by MMP-3, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP-3 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagase, H., Fields, C.G., and Fields, G.B. Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). The Journal of Biological Chemisty 269(33), 20952-20957 (1994).