An RXR agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

V-125

Item No. 37532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[ethyl(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)amino]-3-pyridinecarboxylic acid
CAS Number
1807740-94-8
Molecular Formula
C23H30N2O2
Formula Weight
366.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: Slightly solubleEthanol: Slightly solublePBS (pH 7.2): 0.3 mg/ml
λmax
291 nm
SMILES
CC1(C)C2=C(C=C(C)C(N(CC)C3=CC=C(C(O)=O)C=N3)=C2)C(C)(C)CC1
InChi Code
InChI=1S/C23H30N2O2/c1-7-25(20-9-8-16(14-24-20)21(26)27)19-13-18-17(12-15(19)2)22(3,4)10-11-23(18,5)6/h8-9,12-14H,7,10-11H2,1-6H3,(H,26,27)
InChi Key
HYDUUPGGUIYHGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $40

    Add

    25 mg

    $187

    Add

    100 mg

    $668

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    V-125 is an agonist of retinoid X receptors (RXRs).1 It induces homodimerization of RXR in HCT116 cells in a two-hybrid assay (EC50 = 13.8 nM). V-125 selectively induces transactivation of RXRα in human RXRα-overexpressing HCT116 cells over transactivation of RARα in human RARα-overexpressing HEK293 cells when used at concentrations of 25 and 100 nM, respectively. In vivo, V-125 (80 mg/kg in the diet) inhibits vinyl carbamate-induced lung tumor growth in mice.2 Unlike the RXR agonist bexarotene (Item No. 11571), V-125 does not increase plasma triglyceride or cholesterol levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heck, M.C., C.E., W., Shahani, P.H., et al. Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR)-selective agonists: Analogues of 4‑[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and 6‑(ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic acid (NEt-TMN). J. Med. Chem. 59(19), 8924-8940 (2016).

    2. Reich, L.A., Moerland, J.A., Leal, A.S., et al. The rexinoid V‑125 reduces tumor growth in preclinical models of breast and lung cancer. Sci. Rep. 12(1), 293 (2022).