An inhibitor of N-type voltage-gated calcium channels
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NP-118809

Item No. 37539

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
CAS Number
41332-24-5
Synonyms
  • MK-6721
Molecular Formula
C32H32N2O
Formula Weight
460.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
InChi Code
InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2
InChi Key
VCPMZDWBEWTGNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $98

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    500 mg

    $344

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    Product Description

    NP-118809 is an inhibitor of N-type voltage-gated calcium channels (IC50 = 0.11 µM).1 It is selective for N-type over L-type voltage-gated calcium channels and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 12.2 and 7.4 µM, respectively), as well as a panel of 112 other ion channels, receptors, and signaling targets at 10 µM. NP-118809 (25 mg/kg, i.p.) decreases the number of flinches in the second phase of the formalin test in a rat model of inflammatory pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zamponi, G.W., Feng, Z.P., Zhang, L., et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg. Med. Chem. Lett. 19(22), 6467-6472 (2009).