An inhibitor of N-type voltage-gated calcium channels
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NP-118809

Item No. 37539

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
CAS Number
41332-24-5
Synonyms
  • MK-6721
Molecular Formula
C32H32N2O
Formula Weight
460.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
InChi Code
InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2
InChi Key
VCPMZDWBEWTGNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $98

    Add

    500 mg

    $344

    Add
    Product Description

    NP-118809 is an inhibitor of N-type voltage-gated calcium channels (IC50 = 0.11 µM).1 It is selective for N-type over L-type voltage-gated calcium channels and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 12.2 and 7.4 µM, respectively), as well as a panel of 112 other ion channels, receptors, and signaling targets at 10 µM. NP-118809 (25 mg/kg, i.p.) decreases the number of flinches in the second phase of the formalin test in a rat model of inflammatory pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zamponi, G.W., Feng, Z.P., Zhang, L., et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg. Med. Chem. Lett. 19(22), 6467-6472 (2009).