An ionizable cationic lipidoid
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306-O12B

Item No. 37549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
CAS Number
2566523-06-4
Molecular Formula
C59H115N3O8S8
Formula Weight
1251.1
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
O=C(OCCSSCCCCCCCC)CCN(CCCN(C)CCCN(CCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O
InChi Code
InChI=1S/C59H115N3O8S8/c1-6-10-14-18-22-26-48-71-75-52-44-67-56(63)32-40-61(41-33-57(64)68-45-53-76-72-49-27-23-19-15-11-7-2)38-30-36-60(5)37-31-39-62(42-34-58(65)69-46-54-77-73-50-28-24-20-16-12-8-3)43-35-59(66)70-47-55-78-74-51-29-25-21-17-13-9-4/h6-55H2,1-5H3
InChi Key
FTXIINBPTFOCHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

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    25 mg

    $297

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    Cayman Chemical
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    Product Description

    306-O12B is an ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA targeting Angptl3 (sgAngptl3), the gene encoding angiopoietin-related protein 3, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum Angptl3 protein, LDL, and triglyceride levels.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qiu, M., Glass, Z., Chen, J., et al. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3. Proc. Natl. Acad. Sci. USA 118(10), e2020401118 (2021).