An inhibitor of VEGFA translation
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hVEGF-IN-1

Item No. 37550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl-1-piperazinepropanamide
CAS Number
1637443-98-1
Synonyms
  • Human Vascular Endothelial Growth Factor Inhibitor 1
Molecular Formula
C34H43N7O2
Formula Weight
581.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 2 mg/mlEthanol: 25 mg/ml
λmax
241 nm
SMILES
O=C(CCN1CCN(CC1)C)NC2=C(C3=NC4=C(C(NC5=CC=C(C=C5)OCCN(CC)CC)=N3)C=CC=C4)C=CC=C2
InChi Code
InChI=1S/C34H43N7O2/c1-4-40(5-2)24-25-43-27-16-14-26(15-17-27)35-33-29-11-7-9-13-31(29)37-34(38-33)28-10-6-8-12-30(28)36-32(42)18-19-41-22-20-39(3)21-23-41/h6-17H,4-5,18-25H2,1-3H3,(H,36,42)(H,35,37,38)
InChi Key
VIBJAHJNWHZSJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $768

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    Product Description

    hVEGF-IN-1 is an inhibitor of VEGFA translation.1 It binds to the mRNA encoding VEGF-A (Kd = 4.64 µM) and decreases its translation when used at a concentration of 1.5 µM. hVEGF-IN-1 (3 µM) reduces migration of MCF-7 breast cancer cells. It decreases tumor growth and weight without reducing body weight in an MCF-7 mouse xenograft model when administered at a dose of 7.5 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, S.-K., Wu, Y., Wang, X.-Q., et al. Discovery of small molecules for repressing cap-independent translation of human vascular endothelial growth factor (hVEGF) as novel antitumor agents. J. Med. Chem. 60(13), 5306-5319 (2017).