An inhibitor of LPCAT3
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(R)-HTS-3

Item No. 37563

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2R)-2-(dimethylamino)-2-phenylethyl]-3,5-difluoro-benzamide
CAS Number
2771208-83-2
Molecular Formula
C17H18F2N2O
Formula Weight
304.3
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
FC1=CC(C(NC[C@@H](C2=CC=CC=C2)N(C)C)=O)=CC(F)=C1
InChi Code
InChI=1S/C17H18F2N2O/c1-21(2)16(12-6-4-3-5-7-12)11-20-17(22)13-8-14(18)10-15(19)9-13/h3-10,16H,11H2,1-2H3,(H,20,22)/t16-/m0/s1
InChi Key
SDNDFXUSMLLOMH-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

    $197

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    10 mg

    $365

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    Product Description

    (R)-HTS-3 is an inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3; IC50 = 0.09 µM), an enzyme involved in the synthesis of C20:4-containing phospholipids.1 It reduces the incorporation of arachidonic acid-d8 (Item No. 390010) into phospholipids when used at concentrations of 1, 3, and 10 µM. (R)-HTS-3 (10 µM) reduces RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reed, A., Ichu, T.-A., Milosevich, N., et al. LPCAT3 inhibitors remodel the polyunsaturated phospholipid content of human cells and protect from ferroptosis. ACS Chem. Biol. 17(6), 1607-1618 (2022).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).