A positive allosteric modulator of α7 nAChRs
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CCMI

Item No. 37571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-α-[[(4-chlorophenyl)amino]methylene]-3-methyl-5-isoxazoleacetamide
CAS Number
917837-54-8
Synonyms
  • AVL-3288
  • XY-4083
Molecular Formula
C19H15Cl2N3O2
Formula Weight
388.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C(C1=CC(C)=NO1)=CNC2=CC=C(C=C2)Cl)NC3=CC=C(C=C3)Cl
InChi Code
InChI=1S/C19H15Cl2N3O2/c1-12-10-18(26-24-12)17(11-22-15-6-2-13(20)3-7-15)19(25)23-16-8-4-14(21)5-9-16/h2-11,22H,1H3,(H,23,25)
InChi Key
VMAKIACTLSBBIY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $156

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    25 mg

    $352

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    Product Description

    CCMI is a positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (nAChRs).1 It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice. It decreases the latency to find the platform in the Morris water maze test in a rat model of traumatic brain injury (TBI) induced by parasagittal fluid-percussion.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ng, H.J., Whittemore, E.R., Tran, M.B., et al. Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc. Natl. Acad. Sci. USA 104(19), 8058-8064 (2023).

    2. Titus, D.J., Johnstone, T., Johnson, N.H., et al. Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury. PLoS One 14(10), e0223180 (2019).