A synthetic sterol and neuroprotective agent
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Annaosanchun

Item No. 37572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
androstane-3β,5α,6β-triol
CAS Number
4725-51-3
Molecular Formula
C19H32O3
Formula Weight
308.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleChloroform: Soluble
SMILES
C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C
InChi Code
InChI=1S/C19H32O3/c1-17-7-3-4-14(17)13-10-16(21)19(22)11-12(20)5-9-18(19,2)15(13)6-8-17/h12-16,20-22H,3-11H2,1-2H3/t12-,13-,14-,15-,16+,17-,18+,19-/m0/s1
InChi Key
IFRIPYPBJCUNAG-OTMXHXQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $413

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    Product Description

    Annaosanchun is a synthetic sterol and neuroprotectant agent.1 It increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM. Annaosanchun (10 µM) prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons.2 It reduces neurological and neuromuscular deficits and infarct volume in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at doses of 0.5, 2, or 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Leng, T., Chen, W., et al. A synthetic steroid 5α-androst-3β,5,6β-triol blocks hypoxia/reoxygenation-induced neuronal injuries via protection of mitochondrial function. Steroids 78(10), 996-1002 (2013).

    2. Xue, D., Wei, C., Zhou, Y., et al. TRIOL inhibits rapid intracellular acidification and cerebral ischemic injury: The role of glutamate in neuronal metabolic reprogramming. ACS Chem. Neurosci. 13(14), 2110-2121 (2022).