A TRPV4 agonist
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Product Type

Small Molecule Modulators
Ion Channel Modulators
Activators

Research Area

RN-1747

Item No. 37573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine
CAS Number
1024448-59-6
Molecular Formula
C17H18ClN3O4S
Formula Weight
395.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC=C(S(=O)(N2CCN(CC2)CC3=CC=CC=C3)=O)C([N+]([O-])=O)=C1
InChi Code
InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
InChi Key
ZNLVYSJQUMALEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

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    25 mg

    $296

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    50 mg

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    Product Description

    RN-1747 is an agonist of transient receptor potential vanilloid 4 (TRPV4).1 It selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or transient receptor potential melastatin 8 (TRPM8; EC50s = >100, >30, and >30 µM, respectively). RN-1747 (10 µM) induces inward current in Xenopus oocytes expressing human TRPV4. Topical, but not intravenous, administration of RN-1747 induces hypothermia in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vincent, F., Acevedo, A., Nguyen, M.T., et al. Identification and characterization of novel TRPV4 modulators. Biochem. Biophys. Res. Commun. 389(3), 490-494 (2009).

    2. Vizin, R.C., Scarpellini, C.S., Ishikawa, D.T., et al. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol. (Oxf.) 214(2), 275-289 (2015).