Host: Insect cells • AA: 1-58 (full length) • Tag: C-terminal Rho-1D4 • MW: 8.5 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Proteins

Research Area

Cancer
Angiogenesis

Small Integral Membrane Protein 11 (human, recombinant)

Item No. 37620

Product Insert (PDF)
Technical Information
Synonyms
  • Chromosome 21 Open Reading Frame 51
  • C21orf51
  • SMIM11
  • SMIM11A
  • SMIM11B
  • FAM165B
  • Family with Sequence Similarity 165, Member B
Purity
≥90% estimated by SDS-PAGE
Source
Recombinant human C-terminal Rho-1D4-tagged SMIM11 expressed in insect cells
Amino Acids
1-58 (full length)
MW
8.5 kDa
Formulation (Request formulation change)
10 mM Sodium phosphate, pH 7.0, with 150 mM sodium chloride and 10% glycerol
UniProt Accession №
P58511
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    20 µg

    $393

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Small integral membrane protein 11 (SMIM11) is a single-pass membrane protein encoded by the SMIM11 gene found on human chromosome 21 (HC21), the chromosome that is trisomic in Down syndrome.1 It is composed of a single α helical domain and is expressed in a variety of human and mouse tissues. SMIM11A expression is increased in an in vitro cancer cell model of vascular mimicry, and its silencing via siRNA prevents the formation of tubular structures in the same model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reymond, A., Friedli, M., Henrichsen, C.N., et al. From PREDs and open reading frames to cDNA isolation: Revisiting the human chromosome 21 transcription map. Genomics 78(1-2), 46-54 (2001).

    2. Mingo, G., Pradenas, J., Babbitt, N., et al. SMIM11A, a novel protein involved in the mechanism of vasculogenic mimicry formation in vitro. Cancer Res. 82(12 Suppl), 3841 (2022).