A biotinylated vimentin peptide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Vimentin (140-160)-biotin Peptide (trifluoroacetate salt)

Item No. 37622

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-glycyl-L-glutaminyl-L-glycyl-L-lysyl-L-seryl-L-arginyl-L-leucyl-L-glycyl-L-α-aspartyl-L-leucyl-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-arginyl-L-α-glutamyl-L-leucyl-L-arginyl-L-arginyl-L-glutamine, trifluoroacetate salt
Synonyms
  • VIM (140-160)-biotin
Molecular Formula
C115H190N38O38S2 • XCF3COOH
Formula Weight
2777.1
Purity
≥95%
MW
2,777.0
Formulation (Request formulation change)
A solid
Peptide Sequence
Biotin-GQGKSRLGDLYEEEMRELRRQ
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mLMethanol: Slightly soluble: 0.1-1 mg/mL
SMILES
O=C1N[C@@]([H])([C@]([H])(CS2)N1)[C@@H]2CCCCC(NCC(N[C@@H](CCC(N[H])=O)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(NCC(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O[H])C=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC(N[H])=O)C(O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C115H190N38O38S2.C2HF3O2/c1-56(2)46-73(147-99(178)65(20-15-44-130-114(125)126)140-109(188)78(54-154)151-95(174)61(16-10-11-40-116)134-85(160)52-132-93(172)66(27-33-81(117)156)135-84(159)51-131-83(158)22-9-8-21-80-92-79(55-193-80)152-115(191)153-92)94(173)133-53-86(161)136-77(50-91(170)171)108(187)149-75(48-58(5)6)106(185)150-76(49-59-23-25-60(155)26-24-59)107(186)144-69(31-37-89(166)167)101(180)142-67(29-35-87(162)163)100(179)143-68(30-36-88(164)165)102(181)145-71(39-45-192-7)104(183)138-62(17-12-41-127-111(119)120)97(176)141-70(32-38-90(168)169)103(182)148-74(47-57(3)4)105(184)139-63(18-13-42-128-112(121)122)96(175)137-64(19-14-43-129-113(123)124)98(177)146-72(110(189)190)28-34-82(118)157;3-2(4,5)1(6)7/h23-26,56-58,61-80,92,154-155H,8-22,27-55,116H2,1-7H3,(H2,117,156)(H2,118,157)(H,131,158)(H,132,172)(H,133,173)(H,134,160)(H,135,159)(H,136,161)(H,137,175)(H,138,183)(H,139,184)(H,140,188)(H,141,176)(H,142,180)(H,143,179)(H,144,186)(H,145,181)(H,146,177)(H,147,178)(H,148,182)(H,149,187)(H,150,185)(H,151,174)(H,162,163)(H,164,165)(H,166,167)(H,168,169)(H,170,171)(H,189,190)(H4,119,120,127)(H4,121,122,128)(H4,123,124,129)(H4,125,126,130)(H2,152,153,191);(H,6,7)/t61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,92-;/m0./s1
InChi Key
CTWWUEOQHQKSJC-BUZCXYHISA-N
UniProt Accession №
P08670
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $252

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Vimentin (140-160)-biotin peptide is a biotinylated version of the cytoskeletal intermediate filament protein vimentin, which undergoes citrullination and has been found as the citrullinated form in the synovial fluid of rheumatoid arthritis patients.1 Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) under high calcium concentrations, which can occur during macrophage apoptosis.2,3 Cayman’s Vimentin (140-160)-biotin Peptide is intended for use as a negative control in the detection of autoantibodies against citrullinated vimentin and is the non-citrullinated form of Citrullinated Vimentin (R144) (140-160)-biotin Peptide (Item No. 37624).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bang, H., Egerer, K., Gauliard, A., et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56(8), 2503-2511 (2007).

    2. Li, F.J., Surolia, R., Li, H., et al. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci. Transl. Med. 13(585), eaba2927 (2021).

    3. Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem. Biophys. Res. Commun. 243(3), 641-646 (1998).

    Product Citations

    Jin, F., Li, Y., Li, T., et al. Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice. Part. Fibre. Toxicol. (2026).