A biotinylated and citrullinated mutant vimentin peptide
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Citrullinated Vimentin (G147R) (R145 + R147) (140-160)-biotin Peptide

Item No. 37625

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ
  • Citrullinated VIM (G146R) (R144 + R146)-biotin
MW
2,878.2
Formulation (Request formulation change)
A lyophilized peptide
Peptide Sequence
Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline)
UniProt Accession №
P08670
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $247

    Add
    Cayman Chemical
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    Product Description

    Citrullinated vimentin (G147R) (R145 + R147) (140-160)-biotin peptide is a biotinylated version of a di-citrullinated form of a mutant isoform of the cytoskeleton intermediate filament protein vimentin, vimentinG146R, which has been found in the synovial fluid of patients with rheumatoid arthritis.1 Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) under high calcium concentrations, which can occur during macrophage apoptosis.2,3 Serum levels of immune complexes targeting citrullinated vimentin are increased in patients with rheumatoid arthritis and positive for anti-citrullinated protein antibodies (ACPAs).4 Serum and plasma levels of citrullinated vimentin are also increased in patients with lung cancer or idiopathic pulmonary fibrosis, respectively.5,6 Cayman’s Citrullinated Vimentin (G147R) (R145 + R147) (140-160)-biotin Peptide is intended for use in the detection of autoantibodies against vimentinG146R citrullinated at R145 and R147.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bang, H., Egerer, K., Gauliard, A., et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56(8), 2503-2511 (2007).

    2. Li, F.J., Surolia, R., Li, H., et al. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci. Transl. Med. 13(585), eaba2927 (2021).

    3. Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem. Biophys. Res. Commun. 243(3), 641-646 (1998).

    4. Van Steendam, K., Tilleman, K., De Ceuleneer, M., et al. Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins. Arthritis Res. Ther. 12(4), R132 (2010).

    5. Willumsen, N., Bager, C.L., Leeming, D.J., et al. Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer. Can. Med. 3(5), 1136-1145 (2014).

    6. Li, F.J., Surolia, R., Li, H., et al. Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis. J. Immunol. 199(5), 1596-1605 (2017).