A ferroptosis inducer
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BCP-T.A.

Item No. 37659

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)-methanone
CAS Number
2786829-70-5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlEthanol: 12 mg/ml
SMILES
O=C(N1CCN(C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)CC1)C4=CSC(C#C)=N4
InChi Code
InChI=1S/C23H19Cl2N3OS/c1-2-21-26-20(15-30-21)23(29)28-13-11-27(12-14-28)22(16-3-7-18(24)8-4-16)17-5-9-19(25)10-6-17/h1,3-10,15,22H,11-14H2
InChi Key
XWHYWEHRTWXUFV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    10 mg

    $260

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    Product Description

    BCP-T.A. is a ferroptosis inducer.1 It induces ferroptosis in NCI H522 non-small cell lung cancer (NSCLC) cells (IC50 = 17 nM), an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 (Item No. 17730). BCP-T.A. binds to glutathione peroxidase (GPX4) and increases the accumulation of lipid peroxides in NCI H522 cells when used at a concentration of 0.5 µM. It is cytotoxic to WI38 human lung fibroblasts and mouse embryonic fibroblasts (MEFs; IC50s = 22 and 10 nM, respectively), as well as NCI H522, HT-1080 fibrosarcoma, MDA-MB-468 and MDA-MB-231 breast, and HeLa cervical cancer cells (IC50s = 17, 19, 84, 21, and 242 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karaj, E., Sindi, S.H., Kuganesan, N., et al. Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J. Med. Chem. 65(17), 11788-11817 (2022).