An NSAID and a dual inhibitor of COX and 5-LO
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PGS-IN-1

Item No. 37666

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-2(3H)-furanone
CAS Number
102271-49-8
Synonyms
  • KME-4
  • PGS Inhibitor 1
  • PG Synthetase Inhibitor 1
  • Prostaglandin Synthetase Inhibitor 1
Molecular Formula
C19H26O3
Formula Weight
302.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
218, 238, 318 nm
SMILES
CC(C)(C1=C(C(C(C)(C)C)=CC(/C=C2CCOC\2=O)=C1)O)C
InChi Code
InChI=1S/C19H26O3/c1-18(2,3)14-10-12(9-13-7-8-22-17(13)21)11-15(16(14)20)19(4,5)6/h9-11,20H,7-8H2,1-6H3/b13-9+
InChi Key
DFPYHQJPGCODSB-UKTHLTGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    PGS-IN-1 is a non-steroidal anti-inflammatory drug (NSAID) and a dual inhibitor of COX and 5-lipoxygenase (5-LO; IC50s = 0.44 and 0.85 µM, respectively).1 It is selective for 5-LO over 12-LO (IC50 = >100 µM for the rabbit enzyme ). Oral administration of PGS-IN-1 (10 mg/kg per day) inhibits paw swelling and bone damage in a rat model of M. butyricum-induced arthritis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hidaka, T., Takeo, K., Hosoe, K., et al. Inhibition of polymorphonuclear leukocyte 5-lipoxygenase and platelet cyclooxygenase by α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone (KME-4), a new anti-inflammatory drug. Jpn. J. Pharmacol. 38(3), 267-272 (1985).

    2. Hidaka, T., Hosoe, K., Yamashita, T., et al. Effect of α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone (KME-4), a new anti-inflammatory drug, on the established adjuvant arthritis in rats. Jpn. J. Pharmacol. 42(2), 181-187 (1986).