An ionizable cationic lipid
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Lipid A9

Item No. 37667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-butyloctyl) 10-(N-(3-(dimethylamino)propyl)nonanamido)nonadecanedioate
CAS Number
2036272-50-9
Molecular Formula
C57H112N2O5
Formula Weight
905.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
O=C(CCCCCCCCC(CCCCCCCCC(OCC(CCCCCC)CCCC)=O)N(CCCN(C)C)C(CCCCCCCC)=O)OCC(CCCCCC)CCCC
InChi Code
InChI=1S/C57H112N2O5/c1-8-13-18-21-28-35-45-55(60)59(49-38-48-58(6)7)54(43-33-26-22-24-29-36-46-56(61)63-50-52(39-16-11-4)41-31-19-14-9-2)44-34-27-23-25-30-37-47-57(62)64-51-53(40-17-12-5)42-32-20-15-10-3/h52-54H,8-51H2,1-7H3
InChi Key
XNEHCOKBKFCJSM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $168

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    25 mg

    $368

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    50 mg

    $578

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    Cayman Chemical
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    Product Description

    Lipid A9 is an ionizable cationic lipid (pKa = 6.27) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and siRNA in vivo.1,2 LNPs containing lipid A9 and encapsulating non-stimulatory siRNA increase plasma levels of chemokine (C-C motif) ligand 2 (CCL2), indicating activation of the innate immune response, and decrease body weight in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buschmann, M.D., Carrasco, M.J., Alishetty, S., et al. Nanomaterial delivery systems for mRNA vaccines. Vaccines (Basel) 9(1), 65 (2021).

    2. Holland, R., Lam, K., Jeng, S., et al. Silicon ether ionizable lipids enable potent mRNA lipid nanoparticles with rapid tissue clearance. ACS Nano 18(15), 10374-10387 (2024).