A TLR8 agonist
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CL075

Item No. 37686

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-propyl-thiazolo[4,5-c]quinolin-4-amine
CAS Number
256922-53-9
Synonyms
  • 3M-002
Molecular Formula
C13H13N3S
Formula Weight
243.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
NC1=NC2=C(C=CC=C2)C3=C1N=C(CCC)S3
InChi Code
InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
InChi Key
NFYMGJSUKCDVJR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $97

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    $184

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    25 mg

    $436

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    Cayman Chemical
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    Product Description

    CL075 is a toll-like receptor 8 (TLR8) agonist.1 It induces NF-κB activation in a reporter assay using HEK293 cells expressing recombinant human TLR8 and TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1 to 10 µM. In vivo, CL075 induces antigen-specific antibody responses in rabbits when used as an adjuvant.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gorden, K.K.B., Qiu, X., Battiste, J.J.L., et al. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J. Immunol. 177(11), 8164-8170 (2006).

    2. Lai, C.-Y., Liu, Y.-L., Yu, G.-Y., et al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine 32(43), 5593-5599 (2014).