An sPLA2 (Type IIA) inhibitor
Related Products
Isomer(s)
13058N-Oleoyl-L-Serine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GK241

Item No. 37689

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,2-dioxohexadecyl)-L-valine
CAS Number
1899930-93-8
Molecular Formula
C21H39NO4
Formula Weight
369.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
244 nm
SMILES
CCCCCCCCCCCCCCC(C(N[C@H](C(O)=O)C(C)C)=O)=O
InChi Code
InChI=1S/C21H39NO4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-18(23)20(24)22-19(17(2)3)21(25)26/h17,19H,4-16H2,1-3H3,(H,22,24)(H,25,26)/t19-/m0/s1
InChi Key
ZVJNWONHYXBMJL-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $62

    Add

    5 mg

    $274

    Add

    10 mg

    $486

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    GK241 is a secretory phospholipase A2 (sPLA2) (Type IIA) inhibitor (IC50s = 0.143 and 0.068 µM for the human and mouse enzymes, respectively).1,2 It inhibits IL-1β-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated rat renal mesangial cells when used at concentrations of 3 and 10 µM.3 GK241 also inhibits the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 24 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Theodoropoulou, M.A., Koutoulogenis, G.S., Zhang, L., et al. Identification of a dual inhibitor of secreted phospholipase A2 (GIIA sPLA2) and SARS-CoV-2 main protease. Pharmaceuticals (Basel) 15(8), 961 (2021).

    2. Vasilakaki, S., Barbayianni, E., Leonis, G., et al. Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorg. Med. Chem. 24(8), 1683-1695 (2016).

    3. Vasilakaki, S., Barbayianni, E., Magrioti, V., et al. Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells. Bioorg. Med. Chem. 24(13), 3029-3034 (2016).