A racemic mixture of eicosadienoic acid metabolites
Related Products
Isomer(s)
3771015(R)-HEDE 3772015(S)-HEDE
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(±)15-HEDE

Item No. 37700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15-hydroxy-11Z,13E-eicosadienoic acid
CAS Number
77159-57-0
Molecular Formula
C20H36O3
Formula Weight
324.5
Purity
≥98%
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 1 mg/ml
λmax
234 nm
SMILES
CCCCCC(O)\C=C\C=C\CCCCCCCCCC(=O)O
InChi Code
InChI=1S/C20H36O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h9,11,14,17,19,21H,2-8,10,12-13,15-16,18H2,1H3,(H,22,23)/b11-9-,17-14+
InChi Key
ZTRWPEHMGCHTIT-QWAPPMFBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $49

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    50 µg

    $93

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    100 µg

    $171

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    250 µg

    $400

    Add
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    Product Description

    (±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE (Item No. 37710) and 15(S)-HEDE (Item No. 37720). 15-HEDE is formed from eicosadienoic acid in macrophages.1 It inhibits 5-lipoxygenase (5-LO; IC50 = 35 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rabinovitch, H., Durand, J., Gualde, N., et al. Metabolism of polyunsaturated fatty acids by mouse peritoneal macrophages: The lipoxygenase metabolic pathway. Agents Actions 11(6-7), 580-583 (1981).

    2. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. J. Med. Chem. 30(2), 254-263 (1987).