A DNA alkylating agent
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Dianhydrogalactitol

Item No. 37705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2:5,6-dianhydro-galactitol
CAS Number
23261-20-3
Synonyms
  • Dianhydrodulcitol
  • Dulcitol diepoxide
  • NSC 132313
  • VAL-083
Molecular Formula
C6H10O4
Formula Weight
146.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O[C@@H]([C@@]1([H])CO1)[C@@H]([C@]2([H])CO2)O
InChi Code
InChI=1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
InChi Key
AAFJXZWCNVJTMK-GUCUJZIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $176

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    Product Description

    Dianhydrogalactitol is a hexitol epoxide DNA alkylating agent that has been found in P. caesiopruinosa.1,2 It induces N7-alkylation of guanine and interstrand DNA cross-links in vitro.1 Dianhydrogalactitol (0.5-8 µM) halts the cell cycle at the G2/M phase in U-251MG and T98G glioblastoma cells.3 It decreases the migration and invasion of U251 glioblastoma cells and tube formation of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 12.5 µg/ml.4 Dianhydrogalactitol (2.5 mg/kg) increases survival in a U-251MG mouse xenograft model when administered in combination with the alkylating agent prodrug temozolomide (Item No. 14163).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Institóris, E., and Tamás, J. Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine. Biochem. J. 185(3), 659-666 (1980).

    2. Shanmuganm, K., Srinivasan, M., and Neelakantan, H. Insights into in vitro phenotypic plasticity, growth and secondary metabolites of the mycobiont isolated from the lichen Platygramme caesiopruinosa. Arch. Microbiol. 204(1), 90 (2021).

    3. Jiménez-Alcázar, M., Curiel-García, Á., Nogales, P., et al. Dianhydrogalactitol overcomes multiple temozolomide resistance mechanisms in glioblastoma. Mol. Cancer Ther. 20(6), 1029-1038 (2021).

    4. Jiang, X., Huang, Y., Wang, X., et al. Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed. Pharmacother. 91, 1065-1074 (2017).