An immunosuppressive diketopiperazine derivative of an HSA peptide
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Aspartyl-alanyl-diketopiperazine

Item No. 37715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S-methyl-3,6-dioxo-2S-piperazineacetic acid
CAS Number
110954-19-3
Synonyms
  • DA-DKP
Molecular Formula
C7H10N2O4
Formula Weight
186.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
OC(C[C@H]1C(N[C@H](C(N1)=O)C)=O)=O
InChi Code
InChI=1S/C7H10N2O4/c1-3-6(12)9-4(2-5(10)11)7(13)8-3/h3-4H,2H2,1H3,(H,8,13)(H,9,12)(H,10,11)/t3-,4-/m0/s1
InChi Key
RVLCUCVJZVRNDC-IMJSIDKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $48

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    5 mg

    $202

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    10 mg

    $356

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    25 mg

    $710

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    Product Description

    Aspartyl-alanyl-diketopiperazine is an immunosuppressive diketopiperazine derivative of a human serum albumin (HSA) peptide.1 It reduces antigen-induced TNF-α and IFN-γ production in isolated human T cells when used at a concentration of 500 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimonkevitz, R., Thomas, G., Slone, D.S., et al. A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through Rap1. J. Trauma 64(1), 35-41 (2008).