A PARP1 and PARP2 inhibitor
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Product Type

Biochemicals

Senaparib

Item No. 37722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-1-[[4-fluoro-3-[[4-(2-pyrimidinyl)-1-piperazinyl]carbonyl]phenyl]methyl]-2,4(1H,3H)-quinazolinedione
CAS Number
1401682-78-7
Synonyms
  • IMP-4297
Molecular Formula
C24H20F2N6O3
Formula Weight
478.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.1 mg/ml
λmax
219, 244 nm
SMILES
O=C1NC(N(CC2=CC=C(C(C(N3CCN(CC3)C4=NC=CC=N4)=O)=C2)F)C5=C1C(F)=CC=C5)=O
InChi Code
InChI=1S/C24H20F2N6O3/c25-17-6-5-15(14-32-19-4-1-3-18(26)20(19)21(33)29-24(32)35)13-16(17)22(34)30-9-11-31(12-10-30)23-27-7-2-8-28-23/h1-8,13H,9-12,14H2,(H,29,33,35)
InChi Key
VBTUJTGLLREMNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $68

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    5 mg

    $266

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    10 mg

    $498

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    25 mg

    $829

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    Product Description

    Senaparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, X., Lin, X., Jiang, R., et al. Effect of food on the pharmacokinetics of senaparib (IMP4297) in healthy chinese subjects. Clin. Drug Investig. 42(11), 1009-1016 (2022).