An ER stress inducer
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ERX-41

Item No. 37726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-N-[4-[[(trans-4-methylcyclohexyl)amino]carbonyl]-2-(2-methylpropoxy)phenyl]-3-(2-methylpropoxy)-benzamide
CAS Number
2440087-54-5
Molecular Formula
C38H48N4O9
Formula Weight
704.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: Slightly soluble
λmax
322 nm
SMILES
OCCOC1=C([N+]([O-])=O)C=CC(C(NC2=CC=C(C(NC3=CC=C(C(N[C@@H]4CC[C@@H](C)CC4)=O)C=C3OCC(C)C)=O)C=C2OCC(C)C)=O)=C1
InChi Code
InChI=1S/C38H48N4O9/c1-23(2)21-50-33-18-26(36(44)39-29-11-6-25(5)7-12-29)8-13-30(33)40-37(45)27-9-14-31(34(19-27)51-22-24(3)4)41-38(46)28-10-15-32(42(47)48)35(20-28)49-17-16-43/h8-10,13-15,18-20,23-25,29,43H,6-7,11-12,16-17,21-22H2,1-5H3,(H,39,44)(H,40,45)(H,41,46)/t25-,29-
InChi Key
QOYORXKDWMJNHD-UAHYGDRYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    ERX-41 is an inducer of endoplasmic reticulum (ER) stress.1 It increases the thermal stability of lysosomal acid lipase when used at a concentration of 10 µM in the cellular thermal shift assay (CETSA) but does not inhibit lysosomal acid lipase enzymatic activity at 30 µM. ERX-41 (1 µM) increases ER tubule width, eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3/PERK) and inositol-requiring enzyme 1α (IRE1α) phosphorylation, and splicing of the gene encoding X-box binding protein 1 (XBP1) in SUM149 triple-negative breast cancer (TNBC) cells. It reduces tumor volume and weight in several patient-derived xenograft (PDX) mouse models of TNBC when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X., Viswanadhapalli, S., Kumar, S., et al. Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. Nat. Cancer 3(7), 866-884 (2022).