A DHODH inhibitor
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PfDHODH-IN-1

Item No. 37728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-propenamide
CAS Number
183945-55-3
Synonyms
  • CCHTFP
  • PfDHODH Inhibitor 1
Molecular Formula
C14H11F3N2O2
Formula Weight
296.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
254, 292 nm
SMILES
N#CC(C(NC1=CC=C(C(F)(F)F)C=C1)=O)=C(C2CC2)O
InChi Code
InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,21)
InChi Key
IKNOIAXAHSRIGK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $492

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    Product Description

    PfDHODH-IN-1 is an inhibitor of dihydroorotate dehydrogenase (DHODH; IC50s = 190, 47, and 21 nM for the human, mouse, and rat enzymes, respectively) and a derivative of the DHODH inhibitor A-771726 (Item No. 14404).1,2 It inhibits delayed-type hypersensitivity reactions in mice and rats when administered at doses of 30 and 10 mg/kg, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baldwin, J., Farajallah, A.M., Malmquist, N.A., et al. Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. The Journal of Biological Chemisty 277(44), 41827-41834 (2002).

    2. Kuo, E.A., Hambleton, P.T., Kay, D.P., et al. Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and related compounds. J. Med. Chem. 39(23), 4608-4621 (1996).