An antiviral agent and a derivative of remdesivir
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VV116

Item No. 37745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-5-d)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl, bis(2-methylpropanoate)
CAS Number
2647442-33-7
Synonyms
  • JT001
Molecular Formula
C24H30DN5O7
Formula Weight
502.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 12 mg/mlEthanol: Slightly soluble
λmax
244 nm
SMILES
N#C[C@]1(C2=CC([2H])=C3N2N=CN=C3N)[C@@H]([C@@H]([C@H](O1)COC(C(C)C)=O)OC(C(C)C)=O)OC(C(C)C)=O
InChi Code
InChI=1S/C24H31N5O7/c1-12(2)21(30)33-9-16-18(34-22(31)13(3)4)19(35-23(32)14(5)6)24(10-25,36-16)17-8-7-15-20(26)27-11-28-29(15)17/h7-8,11-14,16,18-19H,9H2,1-6H3,(H2,26,27,28)/t16-,18-,19-,24+/m1/s1/i7D
InChi Key
RVSSLHFYCSUAHY-QXMJNOOVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $124

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    5 mg

    $522

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    10 mg

    $979

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    25 mg

    $2,292

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    Product Description

    VV116 is an antiviral agent and a derivative of the antiviral prodrug remdesivir (Item No. 30354).1 It inhibits viral replication of respiratory syncytial virus (RSV) in A549 cells (EC50 = 1.01 µM). VV116 (25 mg/kg) decreases viral replication and lung viral titer counts in a mouse model of RSV infection. It also decreases alveolar inflammation in RSV-infected mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, R., Zhang, Y., Zheng, W., et al. Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. Signal Transduct. Target. Ther. 7(1), 123 (2022).