A serine palmitoyltransferase inhibitor and antifungal agent
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Lipoxamycin (hemisulfate)

Item No. 37747

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide, hemisulfate
CAS Number
11075-87-9
Synonyms
  • Neoenactin M1
Molecular Formula
C19H36N2O5 • 1/2H2SO4
Formula Weight
421.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
O=S(O)(O)=O.CC(C)CCCC(CCCCCCC(CCN(O)C([C@@H](N)CO)=O)=O)=O.CC(C)CCCC(CCCCCCC(CCN(O)C([C@@H](N)CO)=O)=O)=O
InChi Code
InChI=1S/2C19H36N2O5.H2O4S/c2*1-15(2)8-7-11-16(23)9-5-3-4-6-10-17(24)12-13-21(26)19(25)18(20)14-22;1-5(2,3)4/h2*15,18,22,26H,3-14,20H2,1-2H3;(H2,1,2,3,4)/t2*18-;/m00./s1
InChi Key
LQVOFMWEPHCSIY-IJBYHFJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    Lipoxamycin is an inhibitor of serine palmitoyltransferase (SPT; IC50 = 21 nM for the S. cerevisiae enzyme) and an antifungal agent.1 It also inhibits human SPT with an IC50 value approximately 10-fold lower than the S. cerevisiae enzyme. Lipoxamycin is active against several species of Candida and Cryptococcus, as well as S. cerevisiae (MICs = 0.5-16, 0.25-0.5, and 16 µg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandala, S.M., Frommer, B.R., Thornton, R.A., et al. Inhibition of serine palmitoyl-transferase activity by lipoxamycin. J. Antibiot. (Tokyo) 47(3), 376-379 (1994).