An activator of BMP4 signaling
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SB-4

Item No. 37748

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(4-bromophenyl)methyl]thio]-benzoxazole
CAS Number
100874-08-6
Molecular Formula
C14H10BrNOS
Formula Weight
320.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
BrC1=CC=C(CSC2=NC3=C(O2)C=CC=C3)C=C1
InChi Code
InChI=1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2
InChi Key
JDVOIBFEFVKUPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $31

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    10 mg

    $47

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    25 mg

    $85

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    50 mg

    $108

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    Product Description

    SB-4 is an activator of bone morphogenetic protein 4 (BMP4) signaling.1 It induces BMP4 signaling in a reporter assay using HEK293 cells expressing a recombinant human BMP4 response element (EC50 = 74 nM). SB-4 (10 µM) increases phosphorylation of SMAD1, -5, and -9 in HEK293 cells. It also induces Blimp1 and Tfap2c expression, markers of germline differentiation, in mouse embryonic stem cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bradford, S.T.J., Ranghini, E.J., Grimley, E., et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds. The Journal of Biological Chemisty 294(9), 3125-3136 (2019).

    2. Tehrani, R.S.H., Sayahpour, F.A., and Esfandiari, F. A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation. Differentiation 123, 9-17 (2022).