A triazole-modified sterol and an anticancer agent
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Product Categories

Product Type

Biochemicals
Lipids
Sterol Lipids

Research Area

Cancer
Multidrug Resistance

Fz25

Item No. 37752

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-3-(phenylmethoxy)-17-(1H-1,2,3-triazol-5-yl)-estra-1,3,5(10)-trien-17-ol
CAS Number
2762498-70-2
Molecular Formula
C27H31N3O2
Formula Weight
429.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
280 nm
SMILES
C[C@@]12[C@](CC[C@@]2(O)C3=CN=NN3)([H])[C@@]4([H])[C@](C5=CC=C(OCC6=CC=CC=C6)C=C5CC4)([H])CC1
InChi Code
InChI=1S/C27H31N3O2/c1-26-13-11-22-21-10-8-20(32-17-18-5-3-2-4-6-18)15-19(21)7-9-23(22)24(26)12-14-27(26,31)25-16-28-30-29-25/h2-6,8,10,15-16,22-24,31H,7,9,11-14,17H2,1H3,(H,28,29,30)/t22-,23-,24+,26+,27-/m1/s1
InChi Key
WILNBQOUIDDELX-OBOOOKMBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

    $116

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    Product Description

    Fz25 is a triazole-modified sterol and an anticancer agent.1 It inhibits the proliferation of A2780 ovarian and HT-29 colorectal cancer cells (IC50s = 15.29 and 15.98 µM, respectively). Fz25 decreases the phosphorylation of EGFR and STAT3 in A2780 cells when used at a concentration of 30.58 µM and phosphorylation of ERK, STAT3, and mammalian target of rapamycin (mTOR) in HT-29 cells at 31.96 µM. It reduces the efflux activity of P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in a reporter assay using HEK293 cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ostlund, T., Alotaibi, F., Kyeremateng, J., et al. Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer. Steroids 177, 108950 (2022).