An inhibitor of NEDD8-activating enzyme
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NEDD8 Inhibitor M22

Item No. 37756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine
CAS Number
864420-54-2
Synonyms
  • NAE-IN-M22
  • NEDD8-activating Enzyme Inhibitor M22
Molecular Formula
C20H24Cl2N2
Formula Weight
363.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: Slightly SolubleEthanol: 5 mg/ml
SMILES
ClC1=CC=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C(Cl)=C1
InChi Code
InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2
InChi Key
WMEXQHGRMWPOEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $74

    Add

    1 mg

    $140

    Add

    5 mg

    $293

    Add

    10 mg

    $438

    Add
    Product Description

    NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE).1 It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 non-small cell lung cancer (NSCLC) cells and inhibits the growth of A549 cells (GI50 = 5.5 µM). It inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model when administered at a dose of 60 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, P., Liu, X., Yuan, X., et al. Discovery of a novel NEDD8 activating enzyme inhibitor with piperidin-4-amine scaffold by structure-based virtual screening. ACS Chem. Biol. 11(7), 1901-1907 (2016).