An inhibitor of NEDD8-activating enzyme
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NEDD8 Inhibitor M22

Item No. 37756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine
CAS Number
864420-54-2
Synonyms
  • NAE-IN-M22
  • NEDD8-activating Enzyme Inhibitor M22
Molecular Formula
C20H24Cl2N2
Formula Weight
363.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: Slightly SolubleEthanol: 5 mg/ml
SMILES
ClC1=CC=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C(Cl)=C1
InChi Code
InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2
InChi Key
WMEXQHGRMWPOEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $74

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    1 mg

    $140

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    5 mg

    $293

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    10 mg

    $438

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    Product Description

    NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE).1 It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 non-small cell lung cancer (NSCLC) cells and inhibits the growth of A549 cells (GI50 = 5.5 µM). It inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model when administered at a dose of 60 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, P., Liu, X., Yuan, X., et al. Discovery of a novel NEDD8 activating enzyme inhibitor with piperidin-4-amine scaffold by structure-based virtual screening. ACS Chem. Biol. 11(7), 1901-1907 (2016).