An adenosine A1 receptor positive allosteric modulator
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MIPS521

Item No. 37776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2-amino-4-[3,5-bis(trifluoromethyl)phenyl]-3-thienyl](4-chlorophenyl)-methanone
CAS Number
1146188-19-3
Molecular Formula
C19H10ClF6NOS
Formula Weight
449.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
FC(F)(F)C1=CC(C(F)(F)F)=CC(C2=CSC(N)=C2C(C3=CC=C(Cl)C=C3)=O)=C1
InChi Code
InChI=1S/C19H10ClF6NOS/c20-13-3-1-9(2-4-13)16(28)15-14(8-29-17(15)27)10-5-11(18(21,22)23)7-12(6-10)19(24,25)26/h1-8H,27H2
InChi Key
IVHJBJJHYFIUOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $140

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    25 mg

    $329

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    50 mg

    $585

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    Product Description

    MIPS521 is an adenosine A1 receptor positive allosteric modulator.1 It binds to adenosine A1 receptors (Kb = 11 µM) and enhances adenosine-induced inhibition of forskolin-induced cAMP production in CHO cells expressing recombinant human adenosine A1 receptors when used at concentrations ranging from 0.3 to 30 µM. In vivo, MIPS521 (10 and 30 µg/animal) increases the mechanical paw withdrawal threshold in a rat model of neuropathic pain induced by partial sciatic nerve ligation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Draper-Joyce, C.J., R., B., J., W., et al. Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia. Nature 597(7877), 571-576 (2021).