An NHEJ inhibitor
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SCR130

Item No. 37779

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione
CAS Number
2377858-38-1
Molecular Formula
C19H13Cl2N3O2S
Formula Weight
418.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble (warmed, sonicated)
λmax
249, 292 nm
SMILES
O=C1NC(NC(C12N=C(CC2C3=CC=C(C=C3)Cl)C4=CC=C(Cl)C=C4)=O)=S
InChi Code
InChI=1S/C19H13Cl2N3O2S/c20-12-5-1-10(2-6-12)14-9-15(11-3-7-13(21)8-4-11)24-19(14)16(25)22-18(27)23-17(19)26/h1-8,14H,9H2,(H2,22,23,25,26,27)
InChi Key
QEMQLCCYJLGAKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    SCR130 is an inhibitor of non-homologous end joining (NHEJ) and a derivative of the DNA ligase IV inhibitor SCR7 (Item No. 18015).1 It selectively inhibits DNA ligase IV- over ligase I- or ligase III-mediated end-joining in cell-free assays when used at a concentration of 200 µM. SCR130 is cytotoxic to NALM6 and Reh leukemia and HeLa cervical cancer cells (IC50s = 2.2, 14.1, and 5.9 µM, respectively) and induces DNA double-strand breaks (DSBs) in Reh cells when used at concentrations ranging from 7 to 21 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ray, U., Raul, S.K., Gopinatha, V.K., et al. Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics. Mol. Carcinog. 59(6), 618-628 (2020).