An eIF2B activator
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2BAct

Item No. 37788

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-2-pyrazinecarboxamide
CAS Number
2143542-28-1
Molecular Formula
C19H16ClF3N4O3
Formula Weight
440.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
273 nm
SMILES
O=C(C1=NC=C(C(F)F)N=C1)NC23CC(C2)(C3)NC(COC4=CC=C(C(F)=C4)Cl)=O
InChi Code
InChI=1S/C19H16ClF3N4O3/c20-11-2-1-10(3-12(11)21)30-6-15(28)26-18-7-19(8-18,9-18)27-17(29)14-5-24-13(4-25-14)16(22)23/h1-5,16H,6-9H2,(H,26,28)(H,27,29)
InChi Key
HYQJXXCYOYRNMP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

    $301

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    10 mg

    $470

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    25 mg

    $747

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    Product Description

    2BAct is an activator of eukaryotic translation initiation factor 2B (eIF2B; EC50 = 33 nM in a reporter assay).1 It enhances eIF2B activity in primary fibroblasts isolated from Eif2b5R191H mutant (R191H) mouse embryos (EC50 = 7.3 nM), a model of vanishing white matter (VWM) leukodystrophy. In vivo, 2BAct (30 mg/kg) normalizes body weight gain and prevents the development of motor deficits in R191H mice. It also prevents activation of the integrated stress response and myelin loss in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, Y.L., LeBon, L.B., A.M., Kohlhaas, K.L., et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. eLife 8, e42949 (2019).