An inhibitor of uPA
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ZK 824859

Item No. 37789

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[6-[[3′-(aminomethyl)[1,1′-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-butanoic acid
CAS Number
2254001-81-3
Molecular Formula
C22H20F2N2O4
Formula Weight
414.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
NCC1=CC=CC(C2=CC(OC3=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N3)=CC=C2)=C1
InChi Code
InChI=1S/C22H20F2N2O4/c1-2-19(22(27)28)30-21-18(24)11-17(23)20(26-21)29-16-8-4-7-15(10-16)14-6-3-5-13(9-14)12-25/h3-11,19H,2,12,25H2,1H3,(H,27,28)/t19-/m1/s1
InChi Key
ZDHMLADHONAIES-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $116

    Add

    25 mg

    $273

    Add

    50 mg

    $484

    Add
    Product Description

    ZK 824859 is an inhibitor of urokinase-type plasminogen activator (uPA; IC50s = 79 and 410 nM for the human and mouse proteins, respectively).1 It is selective for human uPA over human tissue-type plasminogen activator (tPA) and plasmin (IC50s = 1,580 and 1,330 nM, respectively) but not selective for mouse uPA over mouse tPA and plasmin (IC50s = 910 and 1,600 nM, respectively). ZK 824859 (25 or 50 mg/kg per day) reduces the incidence of limb weakness and paralysis in mice in a model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Islam, I., Yuan, S., West, C.W., et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg. Med. Chem. Lett. 28(20), 3372-3375 (2018).