An inhibitor of USP2a
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STD1T

Item No. 37791

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5,6,7-tetrahydro-2-[[2-[[5-(2-thienyl)-3-isoxazolyl]methoxy]acetyl]amino]-benzo[b]thiophene-3-carboxamide
CAS Number
893075-58-6
Molecular Formula
C19H19N3O4S2
Formula Weight
417.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 16 mg/ml
λmax
225, 256, 262, 292 nm
SMILES
O=C(C1=C(NC(COCC2=NOC(C3=CC=CS3)=C2)=O)SC4=C1CCCC4)N
InChi Code
InChI=1S/C19H19N3O4S2/c20-18(24)17-12-4-1-2-5-14(12)28-19(17)21-16(23)10-25-9-11-8-13(26-22-11)15-6-3-7-27-15/h3,6-8H,1-2,4-5,9-10H2,(H2,20,24)(H,21,23)
InChi Key
NRPUXFKWYPJDFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

    $392

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    10 mg

    $697

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    25 mg

    $1,390

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    Cayman Chemical
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    Product Description

    STD1T is an inhibitor of ubiquitin-specific protease 2a (USP2a; IC50 = 3.3 µM).1 It is selective for USP2a over USP7 at 10 µM. STD1T (20 µM) decreases cyclin D1 protein levels in HCT116 colon and MCF-7 breast cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tomala, M.D., Magiera-Mularz, K., Kubica, K., et al. Identification of small-molecule inhibitors of USP2a. Eur. J. Med. Chem. 150, 261-267 (2018).