A mixture of (E)-IT-603 and (Z)-IT-603
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(E/Z)-IT-603

Item No. 37792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone
CAS Number
292168-90-2
Molecular Formula
C11H9BrN2O3S
Formula Weight
329.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1NC(NC1=CC2=C(O)C(OC)=CC(Br)=C2)=S
InChi Code
InChI=1S/C11H9BrN2O3S/c1-17-8-4-6(12)2-5(9(8)15)3-7-10(16)14-11(18)13-7/h2-4,15H,1H3,(H2,13,14,16,18)
InChi Key
PYLYAEDUIKQBOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $44

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    5 mg

    $198

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    10 mg

    $329

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    25 mg

    $602

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    Cayman Chemical
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    Product Description

    (E/Z)-IT-603 is a mixture of (E)-IT-603 and (Z)-IT-603.1 (Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM). (Z)-IT-603 inhibits c-Rel DNA binding in an electrophoretic mobility-shift assay (EMSA). Preincubation of (Z)-IT-603 (20 µM) with mouse T cells prevents the development of graft-versus-host disease (GVHD) but does not affect graft-versus-tumor (GVT) activity in a mouse model of allogeneic hematopoietic stem cell transplantation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shono, Y., Tuckett, A.Z., Ouk, S., et al. A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity. Cancer Discov. 4(5), 578-591 (2014).