A mixture of (E)-IT-603 and (Z)-IT-603
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(E/Z)-IT-603

Item No. 37792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone
CAS Number
292168-90-2
Molecular Formula
C11H9BrN2O3S
Formula Weight
329.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1NC(NC1=CC2=C(O)C(OC)=CC(Br)=C2)=S
InChi Code
InChI=1S/C11H9BrN2O3S/c1-17-8-4-6(12)2-5(9(8)15)3-7-10(16)14-11(18)13-7/h2-4,15H,1H3,(H2,13,14,16,18)
InChi Key
PYLYAEDUIKQBOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $198

    Add

    10 mg

    $329

    Add

    25 mg

    $602

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    (E/Z)-IT-603 is a mixture of (E)-IT-603 and (Z)-IT-603.1 (Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM). (Z)-IT-603 inhibits c-Rel DNA binding in an electrophoretic mobility-shift assay (EMSA). Preincubation of (Z)-IT-603 (20 µM) with mouse T cells prevents the development of graft-versus-host disease (GVHD) but does not affect graft-versus-tumor (GVT) activity in a mouse model of allogeneic hematopoietic stem cell transplantation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shono, Y., Tuckett, A.Z., Ouk, S., et al. A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity. Cancer Discov. 4(5), 578-591 (2014).