An NS5A inhibitor
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Ravidasvir (hydrochloride)

Item No. 37794

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-carbamic acid, methyl ester, dihydrochloride
CAS Number
1303533-81-4
Synonyms
  • PPI-668
Molecular Formula
C42H50N8O6 • 2HCl
Formula Weight
835.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
λmax
267, 321 nm
SMILES
O=C(N1[C@@H](CCC1)C2=NC3=CC=C(C4=CC(C=CC(C5=CN=C([C@H](CCC6)N6C([C@H](C(C)C)NC(OC)=O)=O)N5)=C7)=C7C=C4)C=C3N2)[C@H](C(C)C)NC(OC)=O.Cl.Cl
InChi Code
InChI=1S/C42H50N8O6.2ClH/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6;;/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,43,46)(H,44,45)(H,47,53)(H,48,54);2*1H/t33-,34-,35-,36-;;/m0../s1
InChi Key
JYLMWUZJMRNMDA-SPRBZRACSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Ravidasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A).1 It inhibits HCV replication in Huh7 replicon cells containing NS5A from the HCV genotypes 1a, -1b, and 3a with EC50 values of 0.12, 0.01, and 1.14 nM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhong, M., Peng, E., Huang, N., et al. Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor. Bioorg. Med. Chem. Lett. 26(18), 4508-4512 (2016).