A glycosaminoglycan
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Chondroitin Sulfate (sodium salt)

Item No. 37801

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
chondroitin, hydrogen sulfate, monosodium salt
CAS Number
9082-07-9
Synonyms
  • Chondroitin-4-sulfate
  • CSA
Molecular Formula
(C14H22NO15S)n • Na
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
SMILES
O[C@@H]([C@@H]1NC(C)=O)O[C@@H]([C@@H]([C@@H]1O[C@@H](O[C@H]([C@@H]2O)C(O)=O)[C@H]([C@@H]2O)O)OS([O-])(=O)=O)CO[H].[Na+]
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $28

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    10 g

    $53

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    25 g

    $104

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    50 g

    $193

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    Product Description

    Chondroitin sulfate is a glycosaminoglycan (GAG).1,2 It contains a GAG-protein linker region and repeating disaccharide subunits composed of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) that are often sulfonated. Chondroitin sulfate chains of various lengths covalently attach to the surface of proteins via a serine residue in the GAG-protein linker region, forming chondroitin sulfate proteoglycans (CSPGs).2 CSPGs participate in the regulation of many biological activities, such as cell adhesion and migration, organization of brain extracellular matrix (ECM), and the anti-inflammatory response.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwok, J.C.F., Warren, P., and Fawcett, J.W. Chondroitin sulfate: A key molecule in the brain matrix. Int. J. Biochem. Cell Biol. 44(4), 582-586 (2012).

    2. Weisner, J., Landel, I., Reintjes, C., et al. Preclinical efficacy of covalent-allosteric AKT inhibitor borussertib in combination with trametinib in KRAS-mutant pancreatic and colorectal cancer. Cancer Res. 79(9), 2367-2378 (2019).

    3. Mikami, T., and Kitagawa, H. Biosynthesis and function of chondroitin sulfate. Biochim. Biophys. Acta 1830(10), 4719-4733 (2013).

    4. Yamaguchi, Y. Lecticans: Organizers of the brain extracellular matrix. Cell. Mol. Life Sci. 57(2), 276-289 (2000).