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(S)-Norketamine (hydrochloride)

Item No. 37822

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • (−)-Norketamine
Technical Information
Formal Name
(S)-2-amino-2-(2-chlorophenyl)-cyclohexanone, monohydrochloride
CAS Number
83777-70-2
Molecular Formula
C12H14ClNO • HCl
Formula Weight
260.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mLDMSO: 10 mg/mLEthanol: 10 mg/mLPBS (pH 7.2): 5 mg/mL
SMILES
O=C1CCCC[C@]1(N)C2=CC=CC=C2Cl.Cl
InChi Code
InChI=1S/C12H14ClNO.ClH/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15;/h1-2,5-6H,3-4,7-8,14H2;1H/t12-;/m0./s1
InChi Key
CLPOJGPBUGCUKT-YDALLXLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (S)-Norketamine (hydrochloride) (Item No. 37822) is an analytical reference standard categorized as an arylcyclohexylamine.1 (S)-Norketamine is an active metabolite of ketamine (Item Nos. 19389 | 26317 | 11630 | 9001961). (S)-Norketamine has antinociceptive effects in rats.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Coller, J.K., Hutchinson, M.R., et al. The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metab. Dispos. 41(6), 1264-1272 (2013).

    2. Holtman, J.R., Jr., Crooks, P.A., Johnson-Hardy, J.K., et al. Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol. Biochem. Behav. 90(4), 676-685 (2008).

    Product Citations

    Jiang, Q., Han, J., Fine, E.J., et al. Structural basis of opioid receptor activation by PCP and ketamine. Nat. Struct. Mol. Biol. (2026).